EB 382
rac Alminoprofen
CAS: 39718-89-3
Molecular Formula: C13H17NO2
EB 382 - Names and Identifiers
EB 382 - Physico-chemical Properties
| Molecular Formula | C13H17NO2 |
| Molar Mass | 219.28 |
| Density | 1.0697 (rough estimate) |
| Melting Point | 107° |
| Boling Point | 360.1°C (rough estimate) |
| Solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | Light Brown |
| pKa | 4.86±0.50(Predicted) |
| Storage Condition | -20°C Freezer |
| Refractive Index | 1.5100 (estimate) |
| In vitro study | Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both sPLA2 but also COX-2. Alminoprofen (from 0 to 50 μM) induces a dose-related inhibitory response on thelevels of PGE2 formed by the CRL-1517 cell line. |
EB 382 - Risk and Safety
| Toxicity | LD50 orally in mice: 2400 mg/kg (Dumaitre) |
EB 382 - References
| biological activity | Alminoprofen is a non-steroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class. Alminoprofen has both secretory phospholipase A2 (sPLA2) activity and anti-cyclooxygenase (COX-2) activity. |
| Animal Model: | Groups of Wistar Rats (Oedema of the paw) |
| Dosage: | 100 mg/kg |
| Administration: | P.o. |
| Result: | Exerted a statistically significant dose-dependent antagonist action lasting throughout the 2-hr observation period. |
Last Update：2024-04-09 20:52:54
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CAS: 39718-89-3
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